Changes in p53 expression can modify cell shape of ras-transformed fibroblasts and epitheliocytes.

doi:10.1038/sj.onc.1201483

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Article

Changes in p53 expression can modify cell shape of ras-transformed fibroblasts and epitheliocytes.

Oncogene - 11 Dec 1997

Gloushankova N, Ossovskaya V, Vasiliev J, Chumakov P, Kopnin B

Abstract excerpt

p53 plays an important role in restriction of abnormal cell proliferation. Loss of this safeguard function induced by p53 mutations seems to be a key mechanism in oncogenesis. It cannot be excluded however, that in addition to elimination of p53-dependent checkpoints and/or apoptosis p53 mutation...

Topics

Animals
Cell Line
Cell Size
Cell Transformation, Neoplastic
Epithelial Cells
Fibroblasts
Mice
Mutation
Phenotype
Rats
Tumor Suppressor Protein p53
ras Proteins

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