Article
Increased tyrosine phosphorylation in ras transformed fibroblasts occurs prior to manifestation of the transformed phenotype.
Biochemical and biophysical research communications - 31 Jul 1990
Cuadrado A
Abstract excerpt
Murine fibroblasts transformed by ras oncogenes exhibited an increased amount of tyrosine phosphorylated proteins compared to normal cells. The pattern of phosphorylation was similar to that observed in cells chronically stimulated with EGF or PDGF, and is probably due to autocrine stimulation of receptor tyrosine kinases. NIH 3T3 cells transfected with H-ras under the control of a glucocorticoid inducible...
Topics
- Actins
- Animals
- Cell Transformation, Neoplastic
- Dexamethasone
- Fibroblasts
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Phenotype
- Phosphorylation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins