Article
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.
Cell - 11 Mar 1994
Brunner D, Oellers N, Szabad J, Biggs W H, Zipursky S L, Hafen E
Abstract excerpt
In the Drosophila eye, activation of the sevenless (sev) receptor tyrosine kinase is required for the specification of the R7 photoreceptor cell fate. In a genetic screen for mutations that result in the activation of the sev signaling pathway in the absence of the inducing signal, we identified a gain-of-function mutation in rolled (rlSevenmaker [rlSem]), which encodes a homolog of mitogen-activated protein...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Calcium-Calmodulin-Dependent Protein Kinases
- DNA Primers
- Drosophila melanogaster
- Enzyme Activation
- Genes, Dominant
- Genes, ras
- Molecular Sequence Data