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Article

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.

Progress in neurobiology - 1 Feb 1994

Hafen E, Dickson B, Brunner D, Raabe T

Abstract excerpt

The specification of the R7 photoreceptor cell fate in the developing eye of Drosophila depends on the local activation of the sevenless (sev) receptor tyrosine kinase by boss, a protein expressed on the membrane of the neighboring R8 cell. Constitutive activation of the sev receptor results in a dosage dependent increase in the number of R7 cells per ommatidium. Genetic screens have been used to identify...

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PMID: 8008827
DOI: 10.1016/0301-0082(94)90067-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.PMID 8008827Read ↗

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Semantic proximity Read ↗

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Mechanisms of positional signalling in the developing eye of Drosophila studied by ectopic expression of sevenless and rough.Semantic proximity Read ↗

Specification of cell fate in the developing eye of Drosophila.Semantic proximity Read ↗

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.Semantic proximity Read ↗

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.Semantic proximity Read ↗

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.Semantic proximity Read ↗

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SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development.Semantic proximity Read ↗

Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough.Semantic proximity Read ↗

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