Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.

doi:10.1101/gad.7.4.633

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Article

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.

Genes & development - 1 Apr 1993

Doyle H J, Bishop J M

Abstract excerpt

The maternally expressed Drosophila gene torso (tor) is a receptor tyrosine kinase that, when activated, initiates a signal transduction cascade that is responsible for the proper differentiation of the terminal, nonsegmented regions of the embryo. l(1)pole hole, the Drosophila raf-1 serine-threo...

Topics

Alleles
Animals
Cell Differentiation
Chromosome Mapping
Drosophila
Drosophila Proteins
ErbB Receptors
Eye Proteins
Female
Genes, Insect
Genetic Complementation Test
Insect Hormones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Membrane Glycoproteins

Membrane Proteins

Morphogenesis

Mutagenesis, Site-Directed

Protein Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 8384582
DOI: 10.1101/gad.7.4.633

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8384582-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.PMID 8384582Read ↗

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.Semantic proximity Read ↗

Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway.Semantic proximity Read ↗

The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.Semantic proximity Read ↗

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.Semantic proximity Read ↗

The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis.Semantic proximity Read ↗

Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK.Semantic proximity Read ↗

Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase.Semantic proximity Read ↗

Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling.Semantic proximity Read ↗

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.Semantic proximity Read ↗

Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo.Semantic proximity Read ↗

Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein.Semantic proximity Read ↗

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.Semantic proximity Read ↗

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