A screen for mutations that prevent lethality caused by expression of activated sevenless and Ras1 in the Drosophila embryo.

doi:10.1002/(SICI)1520-6408(1998)23:4<347::AID-DVG9>3.0.CO;2-C

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Article

A screen for mutations that prevent lethality caused by expression of activated sevenless and Ras1 in the Drosophila embryo.

Developmental genetics - 1 Jan 1998

Maixner A, Hecker T P, Phan Q N, Wassarman D A

Abstract excerpt

Ras1 plays a critical role in receptor tyrosine kinase (RTK) signal transduction pathways that function during Drosophila development. We demonstrate that mis-expression of constitutively active forms of Ras1 (Ras1V12) and the Sevenless (Sev) RTK (SevS11) during embryogenesis causes lethality due...

Topics

Animals
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Eye Proteins
Gene Expression Regulation, Developmental
Membrane Glycoproteins
Mutation
Receptor Protein-Tyrosine Kinases
ras Proteins

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