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Article

A screen for mutations that prevent lethality caused by expression of activated sevenless and Ras1 in the Drosophila embryo.

Developmental genetics - 1 Jan 1998

Maixner A, Hecker T P, Phan Q N, Wassarman D A

Abstract excerpt

Ras1 plays a critical role in receptor tyrosine kinase (RTK) signal transduction pathways that function during Drosophila development. We demonstrate that mis-expression of constitutively active forms of Ras1 (Ras1V12) and the Sevenless (Sev) RTK (SevS11) during embryogenesis causes lethality due to inappropriate activation of RTK/Ras1 signaling pathways. Genetic and molecular data indicate that the rate of...

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Identifiers

PMID: 9883586
DOI: 10.1002/(SICI)1520-6408(1998)23:4<347::AID-DVG9>3.0.CO;2-C

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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