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Article

Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling.

Genetics - 1 May 2003

Li Jinghong, Li Willis X

Abstract excerpt

Overactivation of receptor tyrosine kinases (RTKs) has been linked to tumorigenesis. To understand how a hyperactivated RTK functions differently from wild-type RTK, we conducted a genome-wide systematic survey for genes that are required for signaling by a gain-of-function mutant Drosophila RTK Torso (Tor). We screened chromosomal deficiencies for suppression of a gain-of-function mutation tor (tor(GOF)), which...

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Identifiers

PMID: 12750336
DOI: 10.1093/genetics/164.1.247
PMCID: PMC1462547

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Source receipt: pubmed, retrieved 7 Sept 2026.

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