Article
Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jun 1993
Hafen E, Dickson B, Brunner T, Raabe T
Abstract excerpt
The specification of the R7 photoreceptor cell fate in the developing eye of Drosophila depends on the local activation of the sevenless (Sev) receptor tyrosine kinase by Boss, a protein expressed on the membrane of the neighbouring R8 cell. Constitutive activation of the Sev receptor results in...
Topics
- Animals
- Caenorhabditis elegans
- Drosophila
- Drosophila Proteins
- Eye Proteins
- Genes, Recessive
- Membrane Glycoproteins
- Mutation
- Photoreceptor Cells
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf
- Receptor Protein-Tyrosine Kinases
- Receptors, Cell Surface
- Signal Transduction
- Species Specificity
- Vertebrates