Article
Isolation of temperature-sensitive mutations of the tyrosine kinase receptor sevenless (sev) in Drosophila and their use in determining its time of action.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1991
Mullins M C, Rubin G M
Abstract excerpt
Loss-of-function mutations in the sevenless (sev) gene in Drosophila result in the failure to differentiate a specific photoreceptor cell type--namely, the R7 cell. The sev gene encodes a cell-surface receptor tyrosine kinase that functions in the presumptive R7 cell to transduce developmental cu...
Topics
- Alleles
- Animals
- DNA Mutational Analysis
- Drosophila Proteins
- Drosophila melanogaster
- Eye Proteins
- Gene Expression
- Membrane Glycoproteins
- Membrane Proteins
- Photoreceptor Cells
- Protein-Tyrosine Kinases
- Receptor Protein-Tyrosine Kinases
- Receptors, Cell Surface
- Structure-Activity Relationship
- Temperature