Isolation of temperature-sensitive mutations of the tyrosine kinase receptor sevenless (sev) in Drosophila and their use in determining its time of action.

Abstract excerpt

Loss-of-function mutations in the sevenless (sev) gene in Drosophila result in the failure to differentiate a specific photoreceptor cell type--namely, the R7 cell. The sev gene encodes a cell-surface receptor tyrosine kinase that functions in the presumptive R7 cell to transduce developmental cues from its neighbors, instructing it to differentiate along the R7 cell pathway. We have isolated...

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