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Article

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.

Nature - 6 Feb 1992

Fortini M E, Simon M A, Rubin G M

Abstract excerpt

Cell-fate specification of R7 photoreceptors in the developing Drosophila eye depends on an inductive signal from neighbouring R8 cells. Mutations in three genes, sevenless (sev), bride-of-sevenless (boss) and seven-in-absentia (sina) cause the R7 precursor to become a non-neural cone cell. The sev gene encodes a receptor protein tyrosine kinase (Sev) localized on the R7 surface, activated by a boss-encoded...

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Source

Identifiers

PMID: 1311054
DOI: 10.1038/355559a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.PMID 1311054Read ↗

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Semantic proximity Read ↗

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Semantic proximity Read ↗

The Drosophila orphan nuclear receptor seven-up requires the Ras pathway for its function in photoreceptor determination.Semantic proximity Read ↗

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.Semantic proximity Read ↗

Specification of cell fate in the developing eye of Drosophila.Semantic proximity Read ↗

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.Semantic proximity Read ↗

The role of the small GTPase Rap in Drosophila R7 photoreceptor specification.Semantic proximity Read ↗

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.Semantic proximity Read ↗

A screen for genes that function downstream of Ras1 during Drosophila eye development.Semantic proximity Read ↗

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.Semantic proximity Read ↗

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.Semantic proximity Read ↗

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.Semantic proximity Read ↗

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