Article
DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.
Cell - 14 Jun 1996
Raabe T, Riesgo-Escovar J, Liu X, Bausenwein B S, Deak P, Maröy P, Hafen E
Abstract excerpt
The specification of the R7 photoreceptor cell in the developing eye of Drosophila is dependent upon activation of the Sevenless (SEV) receptor tyrosine kinase. By screening for mutations that suppress signaling via a constitutively activated SEV protein, we have identified a novel gene, daughter...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Binding Sites
- Blood Proteins
- Crosses, Genetic
- Drosophila
- Drosophila Proteins
- Eye
- Eye Proteins
- Female
- Genes, Insect
- Genes, Suppressor
- Insect Hormones
- Male
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation