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Article

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

Cell - 14 Jun 1996

Raabe T, Riesgo-Escovar J, Liu X, Bausenwein B S, Deak P, Maröy P, Hafen E

Abstract excerpt

The specification of the R7 photoreceptor cell in the developing eye of Drosophila is dependent upon activation of the Sevenless (SEV) receptor tyrosine kinase. By screening for mutations that suppress signaling via a constitutively activated SEV protein, we have identified a novel gene, daughter of sevenless (dos). DOS is required not only for signal transduction via SEV but also in other receptor tyrosine...

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PMID: 8681385
DOI: 10.1016/s0092-8674(00)81274-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.PMID 8681385Read ↗

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.Semantic proximity Read ↗

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Semantic proximity Read ↗

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Semantic proximity Read ↗

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.Semantic proximity Read ↗

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.Semantic proximity Read ↗

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.Semantic proximity Read ↗

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.Semantic proximity Read ↗

A screen for genes that function downstream of Ras1 during Drosophila eye development.Semantic proximity Read ↗

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.Semantic proximity Read ↗

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.Semantic proximity Read ↗

The Son of sevenless gene product: a putative activator of Ras.Semantic proximity Read ↗

A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster.Semantic proximity Read ↗

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