Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila.

Development (Cambridge, England) - 1 Sept 2002

Li Willis X, Agaisse Herve, Mathey-Prevot Bernard, Perrimon Norbert

Abstract excerpt

Malignant transformation frequently involves aberrant signaling from receptor tyrosine kinases (RTKs). These receptors commonly activate Ras/Raf/MEK/MAPK signaling but when overactivated can also induce the JAK/STAT pathway, originally identified as the signaling cascade downstream of cytokine receptors. Inappropriate activation of STAT has been found in many human cancers. However, the contribution of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Consensus Sequence
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Embryo, Nonmammalian

Share to MAP Kinase Signaling System

Share to Receptor Protein-Tyrosine Kinases

Share to STAT Transcription Factors

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 12183376
DOI: 10.1242/dev.129.18.4241
PMCID: PMC3090254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila.PMID 12183376Read ↗

Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling.Semantic proximity Read ↗

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.Semantic proximity Read ↗

Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and MetastasisSemantic proximity Read ↗

A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases.Semantic proximity Read ↗

Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways.Semantic proximity Read ↗

The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.Semantic proximity Read ↗

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.Semantic proximity Read ↗

Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila.Semantic proximity Read ↗

Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs.Semantic proximity Read ↗

A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies in Drosophila melanogaster.Semantic proximity Read ↗

Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase.Semantic proximity Read ↗

Role of receptor tyrosine kinases during Drosophila development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.