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Article

A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster.

Genetics - 1 Nov 2000

Huang A M, Rubin G M

Abstract excerpt

Differentiation of the R7 photoreceptor cell is dependent on the Sevenless receptor tyrosine kinase, which activates the RAS1/mitogen-activated protein kinase signaling cascade. Kinase suppressor of Ras (KSR) functions genetically downstream of RAS1 in this signal transduction cascade. Expression of dominant-negative KSR (KDN) in the developing eye blocks RAS pathway signaling, prevents R7 cell differentiation,...

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Identifiers

PMID: 11063696
DOI: 10.1093/genetics/156.3.1219
PMCID: PMC1461302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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