Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years.

Blood - 15 Sept 2005

Bowen David T, Frew Marion E, Hills Robert, Gale Rosemary E, Wheatley Keith, Groves Michael J, Langabeer Stephen E, Kottaridis Panagiotis D, Moorman Anthony V, Burnett Alan K, Linch David C

Abstract excerpt

The pathogenesis of acute myeloid leukemia (AML) involves the cooperation of mutations promoting proliferation/survival and those impairing differentiation. The RAS pathway has been implicated as a key component of the proliferative drive in AML. We have screened AML patients, predominantly younger than 60 years and treated within 2 clinical trials, for NRAS (n = 1106), KRAS (n = 739), and HRAS (n = 200) hot-spot...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Cytogenetic Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Genes, ras

Share to Leukemia, Myeloid

Share to ras Proteins

Share to Receptor Protein-Tyrosine Kinases

Share to Survival Analysis

Source

Identifiers

PMID: 15951308
DOI: 10.1182/blood-2005-03-0867

Genes

KRAS
NRAS
HRAS
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years.PMID 15951308Read ↗

Clinico-genomic characterization of RAS-mutant acute myeloid leukemia.Semantic proximity Read ↗

RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives.Semantic proximity Read ↗

Implications of NRAS mutations in AML: a study of 2502 patients.Semantic proximity Read ↗

RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group.Semantic proximity Read ↗

RAS mutation analysis in a large cohort of Chinese patients with acute myeloid leukemia.Semantic proximity Read ↗

RAS mutations in acute myeloid leukaemia patients: A review and meta-analysis.Semantic proximity Read ↗

Clinical and proteomic characterization of acute myeloid leukemia with mutated RAS.Semantic proximity Read ↗

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patientsSemantic proximity Read ↗

Clinical implications of RAS mutations in AML: prognostic significance is based upon the involved gene and mutation complexity.Semantic proximity Read ↗

Lack of KRAS gene mutations in chronic myeloid leukemia in Iran.Semantic proximity Read ↗

[Clinical characteristics and prognostic implications of RAS mutations in newly diagnosed acute myeloid leukemia with normal karyotype based on next-generation sequencing analysis].Semantic proximity Read ↗

RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.