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Article

Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes.

Leukemia - 1 Apr 1994

Neubauer A, Greenberg P, Negrin R, Ginzton N, Liu E

Abstract excerpt

Activation of the N- and K-ras proto-oncogenes is the most common molecular abnormality in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). In retrospective studies, approximately 3-36% of MDS patients were reported to harbor a mutated ras proto-oncogene, with some series suggesting the presence of ras-mutations are associated with progressive disease and a poor prognosis. Since hematopoietic...

Topics

Acute Disease
Anemia, Refractory
Anemia, Refractory, with Excess of Blasts
Codon
Genes, ras
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Leukemia, Myeloid
Mutation
Myelodysplastic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Mas

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Identifiers

PMID: 7512175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7512175-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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