Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia.

Leukemia - 1 Oct 1994

Coghlan D W, Morley A A, Matthews J P, Bishop J F

Abstract excerpt

To determine the incidence and prognostic significance of mutation in the N-ras gene in de novo acute myeloid leukemia (AML) we performed an analysis of bone marrow smears from 219 patients with de novo AML treated between 1984 and 1986 and followed for at least six years. DNA extracted from bone marrow smears taken at diagnosis was screened for the presence of mutations in codons 12 and 13 of exon 1 by using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Codon
Share to Genes, ras

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to Prognosis

Share to Restriction Mapping

Source

Identifiers

PMID: 7934163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia.PMID 7934163Read ↗

N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance.Semantic proximity Read ↗

Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.Semantic proximity Read ↗

Codons 12 and 13 of H-ras protooncogene interrupt the progression of DNA synthesis catalyzed by DNA polymerase alpha.Semantic proximity Read ↗

Analysis of N-ras gene mutations in acute myeloid leukemia by allele specific restriction analysis.Semantic proximity Read ↗

N-ras mutation in acute myeloid leukemia: incidence, prognostic significance and value as a marker of minimal residual disease.Semantic proximity Read ↗

The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing.Semantic proximity Read ↗

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years.Semantic proximity Read ↗

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia.Semantic proximity Read ↗

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome.Semantic proximity Read ↗

N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis.Semantic proximity Read ↗

Analysis of ras gene mutations in childhood myeloid leukaemia.Semantic proximity Read ↗

N-ras gene mutations in childhood acute non-lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.