Article
N-ras mutation in acute myeloid leukemia: incidence, prognostic significance and value as a marker of minimal residual disease.
Pathology - 1 Jan 1993
Casey G, Rudzki Z, Roberts M, Hutchins C, Juttner C
Abstract excerpt
The polymerase chain reaction (PCR) and allele specific oligonucleotide (ASO) hybridization have been used to investigate the incidence of N-ras mutation in acute myeloid leukemia (AML). The prognostic significance of these mutations and their value as markers of minimal residual disease have also been assessed. Mutated N-ras alleles were detected in 9 of 69 AML patients (13%). No significant difference in...
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