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Article

Clinico-genomic characterization of RAS-mutant acute myeloid leukemia.

Annals of hematology - 9 Feb 2026

Yuan Robert, Xie Yiyu, Miron Patricia M, Higgins Anne W, Hutchinson Lloyd, Cerny Jan, Patel Shyam A

Abstract excerpt

Somatic mutations within NRAS or KRAS are recurrent in acute myeloid leukemia (AML) and often arise as obligatory late events regarding AML ontogeny. RAS mutations have implications in solid cancers and in AML; however, their prognostic significance and codon-level characteristics are poorly understood, especially regarding response to intensive chemotherapy. There is an unmet need for targeting the RAS pathway....

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Identifiers

PMID: 41661304
DOI: 10.1007/s00277-026-06843-2
PMCID: PMC12886291

Genes

KRAS
NRAS

Provenance

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