Article
N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome.
Blood - 15 Jul 1993
Paquette R L, Landaw E M, Pierre R V, Kahan J, Lübbert M, Lazcano O, Isaac G, McCormick F, Koeffler H P
Abstract excerpt
To evaluate the clinical significance of N-ras mutations in the myelodysplastic syndrome (MDS) archival bone marrow samples from 252 patients were studied for the presence of N-ras exon I mutations using polymerase chain reaction amplification and differential oligonucleotide hybridization. Subse...
Topics
- Bone Marrow
- Chromosome Aberrations
- Genes, ras
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Myelodysplastic Syndromes
- Nucleic Acid Hybridization
- Polymerase Chain Reaction
- Prognosis
- Survival Rate