Article
N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome.
Blood - 15 Jul 1993
Paquette R L, Landaw E M, Pierre R V, Kahan J, Lübbert M, Lazcano O, Isaac G, McCormick F, Koeffler H P
Abstract excerpt
To evaluate the clinical significance of N-ras mutations in the myelodysplastic syndrome (MDS) archival bone marrow samples from 252 patients were studied for the presence of N-ras exon I mutations using polymerase chain reaction amplification and differential oligonucleotide hybridization. Subsequently, clinical information about these patients was obtained and analyzed. Of 220 evaluable patients, 20 (9%) had...
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