Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance.

Blood - 15 Aug 1990

Radich J P, Kopecky K J, Willman C L, Weick J, Head D, Appelbaum F, Collins S J

Abstract excerpt

Point mutations of the N-ras proto-oncogenes have been previously detected in 20% to 60% of samples of acute myelogenous leukemia (AML), but the clinical significance of these mutations is presently unclear. We directly sequenced polymerase chain reaction (PCR) amplified N-ras fragments to determine the frequency of N-ras point mutations in 55 adult patients with de novo AML. Mutations were present in 8 of 55...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Base Sequence
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 2200539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance.PMID 2200539Read ↗

Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.Semantic proximity Read ↗

NRAS mutations in de novo acute leukemia: prevalence and clinical significance.Semantic proximity Read ↗

The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia.Semantic proximity Read ↗

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patientsSemantic proximity Read ↗

N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis.Semantic proximity Read ↗

Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia.Semantic proximity Read ↗

N-ras mutation in acute myeloid leukemia: incidence, prognostic significance and value as a marker of minimal residual disease.Semantic proximity Read ↗

RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing.Semantic proximity Read ↗

Analysis of N-ras gene mutations in acute myeloid leukemia by allele specific restriction analysis.Semantic proximity Read ↗

N-ras mutation detection by pyrosequencing in adult patients with acute myeloid leukemia at a single institution.Semantic proximity Read ↗

Absence of N-ras mutations in myeloid and lymphoid blast crisis of chronic myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.