N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance.

Article

N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance.

Blood - 15 Aug 1990

Radich J P, Kopecky K J, Willman C L, Weick J, Head D, Appelbaum F, Collins S J

Abstract excerpt

Point mutations of the N-ras proto-oncogenes have been previously detected in 20% to 60% of samples of acute myelogenous leukemia (AML), but the clinical significance of these mutations is presently unclear. We directly sequenced polymerase chain reaction (PCR) amplified N-ras fragments to determ...

Topics

Adolescent
Adult
Base Sequence
Female
Gene Frequency
Humans
Leukemia, Myeloid, Acute
Male
Middle Aged
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)

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