Article
Resistance to natural killer cell lysis conferred by TAP1/2 genes in human antigen-processing mutant cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1994
Salcedo M, Momburg F, Hämmerling G J, Ljunggren H G
Abstract excerpt
The human Ag-processing-defective cell line 721.174, and its derivative T2, have a large homozygous deletion in the MHC class II region encompassing the TAP1 and TAP2 as well as the LMP2 and LMP7 genes. A similar, but smaller defect encompassing the TAP1 gene is observed in the 721.134 mutant cel...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Antigen-Presenting Cells
- Carrier Proteins
- Cell Line
- Cytotoxicity, Immunologic
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Killer Cells, Natural
- Mutation
- Transfection