Article
Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules.
The Journal of experimental medicine - 1 Sept 1996
Mandelboim O, Reyburn H T, Valés-Gómez M, Pazmany L, Colonna M, Borsellino G, Strominger J L
Abstract excerpt
Recognition of major histocompatibility complex class I molecules by natural killer (NR) cells leads to inhibition of target cell lysis. Based on the capacity of different human histocompatibility leukocyte antigen (HLA)-C and HLA-B molecules to inhibit target cell lysis by NK lines and clones, t...
Topics
- Alleles
- Cell Survival
- HLA-C Antigens
- Humans
- Killer Cells, Natural
- Mutagenesis, Site-Directed
- Structure-Activity Relationship