Article
Phenotypic studies of natural killer cell subsets in human transporter associated with antigen processing deficiency.
PloS one - 17 Oct 2007
Zimmer Jacques, Bausinger Huguette, Andrès Emmanuel, Donato Lionel, Hanau Daniel, Hentges François, Moretta Alessandro, de la Salle Henri
Abstract excerpt
Peripheral blood natural killer (NK) cells from patients with transporter associated with antigen processing (TAP) deficiency are hyporesponsive. The mechanism of this defect is unknown, but the phenotype of TAP-deficient NK cells is almost normal. However, we noticed a high percentage of CD56(bright) cells among total NK cells from two patients. We further investigated TAP-deficient NK cells in these patients...
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