Novel origin of lpr and gld cells and possible implications in autoimmunity.

Abstract excerpt

The lpr and gld mutations are prime examples of single-gene defects associated with expansion of a unique double-negative (CD4-8-), T-cell receptor alpha:beta + cell population and heightened polyclonal and autoimmune responses. The exact origin of these autoimmunity-inducing/enhancing T cells remains controversial. Here, we review the characteristics of the lpr and gld mutations, and speculate on the possible...

Topics

• Animals
• Autoimmunity
• Bone Marrow
• Disease Models, Animal
• Lymphoproliferative Disorders
• Mice
• Mutation
• Receptors, Antigen, T-Cell
• T-Lymphocytes
• Thymus Gland