Haematopoietic cell transfers between C57BL/6 mice differing at the lpr or gld locus.

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Article

Haematopoietic cell transfers between C57BL/6 mice differing at the lpr or gld locus.

Immunology - 1 Sept 1991

Montecino-Rodriguez E M, Loor F

Abstract excerpt

The generalized lymphoproliferative disease (gld) and lymphoproliferation (lpr) mutations induce the development of strikingly similar autoimmune and lymphoproliferative syndromes in C57BL/6 mice (B6). These syndromes are characterized by hyperglobulinaemia, high levels of circulating autoantibodies and significant splenomegaly and lymphadenopathy resulting principally from the accumulation of a double negative...

Topics

Animals
Antibody-Producing Cells
Autoimmune Diseases
Bone Marrow
Concanavalin A
Female
Hematopoietic Stem Cell Transplantation
Lipopolysaccharides
Lymph Nodes
Lymphoproliferative Disorders
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Mutation

Radiation Chimera

Spleen

Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 1682243
PMCID: PMC1384682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1682243-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Haematopoietic cell transfers between C57BL/6 mice differing at the lpr or gld locus.PMID 1682243Read ↗

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Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.Semantic proximity Read ↗

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.Semantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

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