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Article

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.

The Journal of experimental medicine - 1 Nov 1990

Allen R D, Marshall J D, Roths J B, Sidman C L

Abstract excerpt

Homozygosity for either of the lymphoproliferation (lpr) or generalized lymphoproliferative disease (gld) mutations of mice causes the development of systemic lupus erythematosus-like autoimmune syndromes that are characterized by severe lymphadenopathy and highly elevated serum immunoglobulin levels. Although the mutations are nonallelic, analysis of homozygous lpr/lpr and gld/gld mice on the same strain...

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Identifiers

PMID: 2230649
DOI: 10.1084/jem.172.5.1367
PMCID: PMC2188663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.PMID 2230649Read ↗

Haematopoietic cell transfers between C57BL/6 mice differing at the lpr or gld locus.Semantic proximity Read ↗

Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defect.Semantic proximity Read ↗

<i>Lpr</i> and <i>gld</i>: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative DiseaseSemantic proximity Read ↗

Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.Semantic proximity Read ↗

Bone marrow transplantation from mutant lpr/lpr mice. Functional abnormalities rather than alloantigenic differences appear to determine the development of a graft-vs.-host-like syndrome.Semantic proximity Read ↗

lpr And gld: Single Gene Models Of Systemic Autoimmunity And Lymphoproliferative DiseaseSemantic proximity Read ↗

Tetraparental mice reveal complex cellular interactions of the mutant, autoimmunity-inducing lpr gene.Semantic proximity Read ↗

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.Semantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.Semantic proximity Read ↗

Distinctive expression of lprcg in the heterozygous state on different genetic backgrounds.Semantic proximity Read ↗

Influence of the lpr environment on the lymph node cell phenotypes in C57BL/6 nubg and nulpr chimeras.Semantic proximity Read ↗

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