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Article

<i>Lpr</i> and <i>gld</i>: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1 Apr 1991

Abstract excerpt

The autosomal recessive lpr and gld genes induce in mice multiple autoantibodies and the progressive accumulation of large numbers of non-malignant CD4- CD8- T lymphocytes. The clinical syndromes and immune abnormalities associated with these two nonallelic genes are nearly identical and are also highly dependent on background genes. MRL/lpr mice are particularly severely affected, and they develop a syndrome...

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PMID: 1910678
DOI: 10.1146/annurev.iy.09.040191.001331

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<i>Lpr</i> and <i>gld</i>: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative DiseasePMID 1910678Read ↗

lpr And gld: Single Gene Models Of Systemic Autoimmunity And Lymphoproliferative DiseaseSemantic proximity Read ↗

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The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane.Semantic proximity Read ↗

Novel origin of lpr and gld cells and possible implications in autoimmunity.Semantic proximity Read ↗

Autoimmunity in mice bearing lprcg: a novel mutant gene.Semantic proximity Read ↗

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.Semantic proximity Read ↗

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.Semantic proximity Read ↗

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.Semantic proximity Read ↗

Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.Semantic proximity Read ↗

The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation.Semantic proximity Read ↗

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