Article
Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.
Cancer research - 1 Mar 1994
van der Riet P, Nawroz H, Hruban R H, Corio R, Tokino K, Koch W, Sidransky D
Abstract excerpt
In order to define more clearly the role of chromosome 9 loss in head and neck squamous cell carcinoma (HNSCC), 29 invasive carcinomas and 17 preinvasive lesions were analyzed for loss of heterozygosity (LOH) on chromosome 9. We found LOH in 21 of 29 (72%) HNSCC tumors using highly polymorphic microsatellite markers. In 17 of 21, LOH was found at all informative sites on the p arm with no LOH of the q arm....
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