Article
Prognostic implications of loss of heterozygosity at 8p21 and 9p21 in head and neck squamous cell carcinoma.
International journal of cancer - 20 Aug 2004
Coon Steven W, Savera Adnan T, Zarbo Richard J, Benninger Michael S, Chase Gary A, Rybicki Benjamin A, Van Dyke Daniel L
Abstract excerpt
Loss of heterozygosity (LOH) in chromosomal regions that harbor tumor suppressor genes from tumor tissue may lead to decreased survival time in cancer patients with squamous cell carcinoma of the head and neck (HNSCC). We studied 8 regions frequently lost in HNSCC in 150 patients having a primary diagnosis of HNSCC. Tumor and normal tissue DNA were genotyped for microsatellite repeat markers in 8 unlinked...
Topics
- Adult
- Aged
- Carcinoma, Squamous Cell
- Chromosomes, Human, Pair 8
- Chromosomes, Human, Pair 9
- DNA, Neoplasm
- Female
- Genetic Markers
- Genotype
- Head and Neck Neoplasms
- Humans
- Loss of Heterozygosity
- Male
- Middle Aged