Deletion mapping in squamous cell carcinomas of the esophagus defines a region containing a tumor suppressor gene within a 4-centimorgan interval of the distal long arm of chromosome 9.

Abstract excerpt

Recent studies in our laboratory indicated that inactivation of a putative tumor suppressor gene on chromosome 9q is likely to be associated with an early step of esophageal carcinogenesis. To further define a region containing the putative tumor suppressor gene, we have examined loss of heterozygosity in 37 esophageal squamous cell carcinomas using 14 microsatellite markers mapped to 9q31-q34.1. Loss of...

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