Article
Two regions of deletion in 9p22- p24 in neuroblastoma are frequently observed in favorable tumors.
Cancer genetics and cytogenetics - 1 May 2002
Giordani Lucia, Iolascon Achille, Servedio Veronica, Mazzocco Katia, Longo Luca, Tonini Gian Paolo
Abstract excerpt
Neuroblastoma is a tumor of infancy that presents several chromosomal abnormalities. Nonrandom deletion of chromosome arm 9p has been identified in primary neuroblastoma suggesting the presence of a tumor suppressor gene located on this chromosome. In previous work, we showed that CDKN2A and CDKN2B genes, mapped at 9p21, were not deleted in neuroblastoma cells. In the present article, we refine the deleted region...
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