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Article

Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes.

Cancer research - 1 Oct 1994

Loughran O, Edington K G, Berry I J, Clark L J, Parkinson E K

Abstract excerpt

Human chromosomes 1,4,6, and 9 harbor genes which induce cellular senescence in vitro but a role for their inactivation in human tumors is not established. To investigate this we searched for loss of heterozygosity (LOH) on these chromosomes in keratinocyte cultures obtained from different stages of human squamous cell carcinoma progression. There was consistent LOH between markers D9S171 and D9S157 in 9 of 9...

Topics

Calcium-Binding Proteins
Carcinoma, Squamous Cell
Cells, Cultured
Chromosome Deletion
Chromosomes, Human, Pair 9
Head and Neck Neoplasms
Humans
Keratinocytes
Phenotype
S100 Calcium-Binding Protein A4

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S100 Proteins

Source

Identifiers

PMID: 7923114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7923114-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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