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Article

Loss of heterozygosity at the 9p21-24 region and identification of BRM as a candidate tumor suppressor gene in head and neck squamous cell carcinoma.

Cancer investigation - 1 Jul 2009

Gunduz Esra, Gunduz Mehmet, Ali Mahmoud Al Sheik, Beder Levent, Tamamura Ryo, Katase Naoki, Tominaga Susumu, Yamanaka Noboru, Shimizu Kenji, Nagatsuka Hitoshi

Abstract excerpt

We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to be a target for deletion of the 9p21 region. However, novel frequent chromosomal deletion and a...

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Share to Carcinoma, Squamous Cell
Share to Chromosomes, Human, Pair 9

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Identifiers

PMID: 19488910
DOI: 10.1080/07357900802563010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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