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Article

Sequential loss of heterozygosity at microsatellite motifs in preinvasive and invasive head and neck squamous carcinoma.

Cancer research - 15 Jun 1995

el-Naggar A K, Hurr K, Batsakis J G, Luna M A, Goepfert H, Huff V

Abstract excerpt

Studies of sequential molecular alterations in noninvasive and invasive head and neck squamous carcinoma are few in number. Consequently, the genetic changes associated with the neoplastic transformation of these carcinomas have not been defined. To identify chromosomal alterations in preinvasive and invasive head and neck squamous carcinoma, we analyzed DNA from microdissected normal squamous epithelium, severe...

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PMID: 7780981

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