Article
Establishment of T-cell lines from infiltrated NOD islets by stimulation of specific T-cell receptor V beta segments.
Journal of autoimmunity - 1 Aug 1993
Maugendre D, Legrand B, Olivi M, Bedossa P, Bach J F, Carnaud C
Abstract excerpt
The aims of this study were firstly to establish permanent T-cell lines from infiltrated NOD islets, by repeated stimulation of the antigen T-cell receptor with anti-V beta monoclonal antibodies (mAb) and, secondly, to characterize some of their cytotoxic and pathogenic properties. The use of ant...
Topics
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- CD4-Positive T-Lymphocytes
- CD8 Antigens
- Cell Division
- Cell Line
- Clone Cells
- Diabetes Mellitus, Type 1
- Female
- Islets of Langerhans
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred NOD
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Stimulation, Chemical