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Article

T cell receptor restriction of diabetogenic autoimmune NOD T cells

18 Mar 1997

Abstract excerpt

Restricted use of T cell receptor (TCR) gene segments is characteristic of several induced autoimmune disease models. TCR sequences have previously been unavailable for pathogenic T cells which react with a defined autoantigen in a spontaneous autoimmune disease. The majority of T cell clones, derived from islets of NOD mice which spontaneously develop type I diabetes, react with insulin peptide B-(9-23). We have...

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Identifiers

PMID: 9122227
DOI: 10.1073/pnas.94.6.2518

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