Article
In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18.
European journal of immunology - 1 May 2011
Wen Li, Green Elizabeth A, Stratmann Thomas, Panosa Anaïs, Gomis Ramon, Eynon Elizabeth E, Flavell Richard A, Mezquita Jovita A, Mora Conchi
Abstract excerpt
CD4(+) T lymphocytes are required to induce spontaneous autoimmune diabetes in the NOD mouse. Since pancreatic β cells upregulate Fas expression upon exposure to pro-inflammatory cytokines, we studied whether the diabetogenic action of CD4(+) T lymphocytes depends on Fas expression on target cells. We assayed the diabetogenic capacity of NOD spleen CD4(+) T lymphocytes when adoptively transferred into a NOD mouse...
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