Autoreactive T cells in normal mice: unrestricted recognition of self peptides on dendritic cell I-A molecules by CD4-CD8- T cell receptor alpha/beta+ T cell clones expressing V beta 8.1 gene segments.

doi:10.1002/eji.1830200611

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Article

Autoreactive T cells in normal mice: unrestricted recognition of self peptides on dendritic cell I-A molecules by CD4-CD8- T cell receptor alpha/beta+ T cell clones expressing V beta 8.1 gene segments.

European journal of immunology - 1 Jun 1990

Seman M, Boudaly S, Roger T, Morisset J, Pham G

Abstract excerpt

CD4-CD8- double-negative (DN) and CD4+CD8- T cell clones were derived from splenic precursors resistant to killing by anti-Thy-1, -CD5, -CD4 and -CD8 monoclonal antibodies and complement. Both DN and CD4+ clones express functional T cell receptor (TcR) alpha/beta and exhibit strong autoreactivity in vitro. DN cells can be induced to proliferate by dendritic cells (DC) of all haplotypes tested, although this...

Topics

Animals
Autoimmunity
Clone Cells
Dendritic Cells
Female
Haplotypes
Histocompatibility Antigens Class II
Lymphocyte Activation
Male
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred DBA

Mice, Inbred Strains

Peptides

Phenotype

Receptors, Antigen, T-Cell

Receptors, Antigen, T-Cell, alpha-beta

Spleen

Source

Open in PubMed

Identifiers

PMID: 2142457
DOI: 10.1002/eji.1830200611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2142457-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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