Article
Phenotypic and functional characterization of human T cell clones indirectly activated against adult pig islet cells.
Xenotransplantation - 1 Jan 2006
Lindeborg Ellinor, Kumagai-Braesch Makiko, Möller Erna
Abstract excerpt
BACKGROUND: Xenotransplanted patients produce xenospecific IgG1 antibodies directed against epitopes other than Galalpha1,3Gal. IgG1 antibody production is believed to be dependent upon T cell help. Therefore, as a natural continuation of our work aimed at characterizing the xenoimmune antibody response against pig islet cells, we have also examined the T cell response. T cell reactivity against islet cells is...
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