Article
Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice.
European journal of immunology - 1 Aug 1994
Wegmann D R, Norbury-Glaser M, Daniel D
Abstract excerpt
Numerous investigation have demonstrated that T cells are involved in destruction of beta cells in the NOD mouse, a widely studied model of type I diabetes. In this report we describe a series of islet-specific T cell lines established from islet-infiltrating lymphocytes obtained from individual...
Topics
- Animals
- Cell Line
- Clone Cells
- Diabetes Mellitus, Type 1
- Female
- Insulin
- Islets of Langerhans
- Lymphocyte Activation
- Mice
- Phenotype
- Prediabetic State
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocyte Subsets