Article
Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice.
European journal of immunology - 1 Aug 1994
Wegmann D R, Norbury-Glaser M, Daniel D
Abstract excerpt
Numerous investigation have demonstrated that T cells are involved in destruction of beta cells in the NOD mouse, a widely studied model of type I diabetes. In this report we describe a series of islet-specific T cell lines established from islet-infiltrating lymphocytes obtained from individual pre-diabetic NOD mice as well as a large panel of clones derived from these lines. Proliferation assays indicated that...
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