Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

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Article

Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1995

Santamaria P, Utsugi T, Park B J, Averill N, Kawazu S, Yoon J W

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice results from a cell-mediated autoimmune process against pancreatic beta-cells. We have shown that beta-cell-cytotoxic CD8+ T cell clones can transfer IDDM to irradiated NOD mice if co-injected with nondiabetogenic CD4+ spleen T cells. To determine whether CTLs recruited to pancreatic islets recognize a restricted set of local Ags, we...

Topics

Amino Acid Sequence
Animals
Base Sequence
CD8-Positive T-Lymphocytes
Cell Line
Clone Cells
Cytotoxicity, Immunologic
DNA
Diabetes Mellitus, Type 1
Female
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Genetic Variation

Islets of Langerhans

Male

Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Source

Open in PubMed

Identifiers

PMID: 7868915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7868915-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.PMID 7868915Read ↗

beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct.Semantic proximity Read ↗

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Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice.Semantic proximity Read ↗

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