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Article

Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1995

Santamaria P, Utsugi T, Park B J, Averill N, Kawazu S, Yoon J W

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice results from a cell-mediated autoimmune process against pancreatic beta-cells. We have shown that beta-cell-cytotoxic CD8+ T cell clones can transfer IDDM to irradiated NOD mice if co-injected with nondiabetogenic CD4+ spleen T cells. To determine whether CTLs recruited to pancreatic islets recognize a restricted set of local Ags, we...

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PMID: 7868915

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Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.PMID 7868915Read ↗

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Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD MiceSemantic proximity Read ↗

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