Article
Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool.
Diabetes - 1 Sept 2001
Serreze D V, Johnson E A, Chapman H D, Graser R T, Marron M P, DiLorenzo T P, Silveira P, Yoshimura Y, Nathenson S G, Joyce S
Abstract excerpt
A broad repertoire of pancreatic beta-cell autoreactive T-cells normally contributes to the development of type 1 diabetes in NOD mice. However, it has been unknown if a large reduction in the precursor pool from which autoreactive T-cells are drawn would inhibit the development of type 1 diabetes. To address this issue, we reduced the precursor frequency of autoreactive T-cells in NOD mice through allelic...
Topics
- Alleles
- Animals
- Autoimmunity
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Division
- Clone Cells
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Genetic Vectors