Article
Characteristics and in vivo homing of long-term T-cell lines and clones derived from tumor-draining lymph nodes.
Cancer research - 15 May 1994
Matsumura T, Sussman J J, Krinock R A, Chang A E, Shu S
Abstract excerpt
Lymph nodes draining a progressively growing tumor contain T-cells which can be activated sequentially by anti-CD3 and IL-2 to differentiate into tumor-specific effector cells. In this study, long-term cultured T-cell lines were established from activated MCA 106 tumor-draining lymph node cells by periodic stimulation with irradiated tumor cells in the presence of low concentrations of IL-2 (< or = 60...
Topics
- Animals
- Cell Line
- Female
- Fibrosarcoma
- Immunotherapy, Adoptive
- Lymph Nodes
- Lymphocyte Activation
- Lymphocyte Subsets
- Lymphocytes, Tumor-Infiltrating
- Methylcholanthrene
- Mice