Article
Successful in vitro priming of EBV-specific CD8+ T cells endowed with strong cytotoxic function from T cells of EBV-seronegative children.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Sept 2006
Comoli P, Ginevri F, Maccario R, Frasson C, Valente U, Basso S, Labirio M, Huang G-C, Verrina E, Baldanti F, Perfumo F, Locatelli F
Abstract excerpt
Epstein-Barr virus (EBV)-seronegative transplant recipients are at high risk of developing EBV-associated post-transplant lymphoproliferative disorder (PTLD), and would maximally benefit from an EBV-directed T-cell therapy for prevention or treatment of PTLD. So far, efforts to activate CD8+ EBV-specific cytotoxic T lymphocytes (CTL) endowed with high specific cytotoxicity from EBV-seronegative children have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.