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Article

Infrequent involvement of p53 mutations and loss of heterozygosity of 17p in the tumorigenesis of renal cell carcinoma.

The Journal of urology - 1 Oct 1993

Uchida T, Wada C, Shitara T, Egawa S, Mashimo S, Koshiba K

Abstract excerpt

Restriction fragment length polymorphism (RFLP) analysis and the polymerase chain reaction of the single-strand conformation polymorphism (PCR-SSCP) method were conducted to assess the loss of heterozygosity of chromosome 17p and mutations of the p53 gene in 30 surgical specimens of human renal cell carcinoma. Six of 29 tumors (20.6%) showed loss of heterozygosity on chromosome 17p in RFLP analysis, and in none...

Read the complete abstract on PubMed

Topics

Carcinoma, Renal Cell
Chromosomes, Human, Pair 17
Genes, p53
Heterozygote
Humans
In Vitro Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Kidney Neoplasms

Mutation

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 8103806
DOI: 10.1016/s0022-5347(17)35764-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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