Infrequent involvement of p53 mutations and loss of heterozygosity of 17p in the tumorigenesis of renal cell carcinoma.

doi:10.1016/s0022-5347(17)35764-6

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Article

Infrequent involvement of p53 mutations and loss of heterozygosity of 17p in the tumorigenesis of renal cell carcinoma.

The Journal of urology - 1 Oct 1993

Uchida T, Wada C, Shitara T, Egawa S, Mashimo S, Koshiba K

Abstract excerpt

Restriction fragment length polymorphism (RFLP) analysis and the polymerase chain reaction of the single-strand conformation polymorphism (PCR-SSCP) method were conducted to assess the loss of heterozygosity of chromosome 17p and mutations of the p53 gene in 30 surgical specimens of human renal c...

Topics

Carcinoma, Renal Cell
Chromosomes, Human, Pair 17
Genes, p53
Heterozygote
Humans
In Vitro Techniques
Kidney Neoplasms
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

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