Article
Poor correlation with loss of heterozygosity on chromosome 17p and p53 mutations in ovarian cancers.
Gynecologic oncology - 1 Nov 1996
Sakamoto T, Nomura N, Mori H, Wake N
Abstract excerpt
To define the target of chromosome 17p deletions, allelic losses in the 17p11.2 to 13.3 regions of 32 ovarian cancers were investigated. Twenty-one (68%) of 31 informative cancers had deletions on chromosome 17p. None of these 21 cancers involved deletions in the entire chromosome 17p even if deletions of a small chromosome region were infrequent. Of these 21, 17 cancers contained deletions at 17p13.1 or...
Topics
- Alleles
- Blotting, Southern
- Carcinoma
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA, Neoplasm
- DNA, Satellite
- Female
- Gene Deletion
- Genes, p53
- Genes, ras
- Humans