Mutation of the p53 tumour suppressor gene occurs preferentially in the chromophobe type of renal cell tumour.

doi:10.1002/(SICI)1096-9896(199702)181:2<136::AID-PATH766>3.0.CO;2-2

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Article

Mutation of the p53 tumour suppressor gene occurs preferentially in the chromophobe type of renal cell tumour.

The Journal of pathology - 1 Feb 1997

Contractor H, Zariwala M, Bugert P, Zeisler J, Kovacs G

Abstract excerpt

Genomic DNA from 30 non-papillary and 20 chromophobe renal cell carcinomas (RCCs), 30 papillary renal cell tumours, and 20 renal oncocytomas was screened for the presence of mutations in exons 5-8 of the p53 tumour suppressor gene by polymerase chain reaction-single strand conformation polymorphi...

Topics

Carcinoma, Renal Cell
Chromosome Deletion
Chromosomes, Human, Pair 17
Genes, p53
Humans
Kidney Neoplasms
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

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