Article
Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype.
Anti-cancer drugs - 1 Jun 1993
Assaraf Y G, Borgnia M J
Abstract excerpt
Chinese hamster ovary (CHO) T19 cells express a stable P-glycoprotein (P-170)-dependent multidrug resistance (MDR) phenotype and display a 24- to 29-fold cross-resistance to the lipophilic antifolates piritrexim (PTX) and trimetrexate (TMTX). We have examined the ability of various modulators of...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- CHO Cells
- Carrier Proteins
- Cricetinae
- Drug Interactions
- Drug Resistance
- Membrane Glycoproteins
- Methotrexate
- Phenotype
- Pyrimethamine
- Pyrimidines
- Quinidine
- RNA, Messenger
- Tetrahydrofolate Dehydrogenase
- Trimetrexate