Article
Clinical trials of agents that reverse multidrug resistance. A literature review.
Cancer - 15 Dec 1993
Raderer M, Scheithauer W
Abstract excerpt
BACKGROUND: The discovery of the P-170 glycoprotein as a mediator of multidrug resistance (MDR) represents one of the most important research accomplishments in antineoplastic pharmacology during the last decade. Demonstration of P-170 in epithelial tissues, untreated and chemotherapeutically pretreated human malignancies, and identification of various agents capable of reversing resistance in vitro generated...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Clinical Trials as Topic
- Cyclosporins
- Drug Resistance
- Humans
- Phenotype
- Quinidine
- Tamoxifen
- Trifluoperazine
- Verapamil