Article
Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.
Cancer research - 1 Apr 1998
Sehested M, Wessel I, Jensen L H, Holm B, Oliveri R S, Kenwrick S, Creighton A M, Nitiss J L, Jensen P B
Abstract excerpt
Anticancer drugs targeted to the nuclear enzyme DNA topoisomerase II are classified as poisons that lead to DNA breaks or catalytic inhibitors that appear to completely block enzyme activity. To examine the effects of the bisdioxopiperazine class of catalytic inhibitors to topoisomerase II, we in...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Neoplasm
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Base Sequence
- Blotting, Western
- CHO Cells
- Cricetinae
- DNA Topoisomerases, Type II
- DNA, Neoplasm
- DNA-Binding Proteins
- Diketopiperazines